Pseudomonas aeruginosa UCBPP-PA14, PA14_11550 (dxs)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_11550
Name	dxs
Replicon	chromosome
Genomic location	997819 - 999702 (- strand)

Cross-References

RefSeq	YP_789075.1
GI	116052081
EC Number	2.2.1.7
Entrez	4382715
INSDC	ABJ13317.1
NCBI Locus Tag	PA14_11550
UniParc	UPI00001299EC
UniProtKB Acc	Q02SL1
UniProtKB ID	DXS_PSEAB
UniRef100	UniRef100_B7V7R4
UniRef50	UniRef50_Q487D3
UniRef90	UniRef90_B7V7R4

Product

Feature Type	CDS
Coding Frame	1
Product Name	1-deoxy-D-xylulose-5-phosphate synthase
Synonyms
Evidence for Translation
Charge (pH 7)	-14.76
Kyte-Doolittle Hydrophobicity Value	-0.107
Molecular Weight (kDa)	68.0
Isoelectric Point (pI)	5.50

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
8A29	TRANSFERASE	06/02/22	Apo 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa	Pseudomonas aeruginosa LESB58	2.1	X-RAY DIFFRACTION	93.9
8A4D	TRANSFERASE	06/10/22	1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa with thiamine analog inhibitor	Pseudomonas aeruginosa LESB58	2.2	X-RAY DIFFRACTION	93.9
8A45	TRANSFERASE	06/10/22	Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa with 2-acetyl thiamine diphosphate	Pseudomonas aeruginosa LESB58	2	X-RAY DIFFRACTION	93.9
8A5K	TRANSFERASE	06/15/22	Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding	Pseudomonas aeruginosa LESB58	2.3	X-RAY DIFFRACTION	93.9

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 617 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG001640 (536 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_11550 Search term: dxs Search term: 1-deoxy-D-xylulose-5-phosphate synthase

Human Homologs

References