Pseudomonas aeruginosa UCBPP-PA14, PA14_12060 (pbpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_12060
Name
pbpA
Replicon chromosome
Genomic location 1040914 - 1042854 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14

Cross-References

RefSeq YP_789116.1
GI 116052041
Entrez 4383490
INSDC ABJ13277.1
NCBI Locus Tag PA14_12060
UniParc UPI00000D4222
UniProtKB Acc Q02SH0
UniProtKB ID Q02SH0_PSEAB
UniRef100 UniRef100_G3XCV7
UniRef50 UniRef50_G8PXZ8
UniRef90 UniRef90_G3XCV7

Product

Feature Type CDS
Coding Frame 1
Product Name
penicillin-binding protein 2
Synonyms
Evidence for Translation
Charge (pH 7) 5.83
Kyte-Doolittle Hydrophobicity Value -0.332
Molecular Weight (kDa) 72.2
Isoelectric Point (pI) 8.49

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7KIS HYDROLASE/Inhibitor/Antibiotic 10/24/20 Crystal structure of Pseudomonas aeruginosa PBP2 in complex with WCK 5153 Pseudomonas aeruginosa 2.869 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Ceftazidime DB00438 DrugBank 5.1.4 Q9X6V3 Penicillin-binding protein 2 100.0 646 0.0e+00
Cefepime DB01413 DrugBank 5.1.4 Q9X6V3 Penicillin-binding protein 2 100.0 646 0.0e+00

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 575 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001680 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_12060
Search term: pbpA

Human Homologs

References

No references are associated with this feature.