Pseudomonas aeruginosa UCBPP-PA14, PA14_13660 (tpbA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_13660
Name
tpbA
Replicon chromosome
Genomic location 1174167 - 1174823 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_789236.1
GI 116051921
Entrez 4381929
INSDC ABJ13157.1
NCBI Locus Tag PA14_13660
UniParc UPI00003961FB
UniProtKB Acc Q02S50
UniProtKB ID Q02S50_PSEAB
UniRef100 UniRef100_Q02S50
UniRef50 UniRef50_Q9HXC7
UniRef90 UniRef90_Q9HXC7

Product

Feature Type CDS
Coding Frame 1
Product Name
protein tyrosine phosphatase TpbA
Product Name Confidence: Class 1
Synonyms hypothetical protein
Evidence for Translation
Charge (pH 7) 1.34
Kyte-Doolittle Hydrophobicity Value -0.121
Molecular Weight (kDa) 24.0
Isoelectric Point (pI) 7.60

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Periplasmic Class 1
cell fractionation evidence
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2M3V HYDROLASE 01/26/13 Solution structure of tyrosine phosphatase related to biofilm formation A (TpbA) from Pseudomonas aeruginosa Pseudomonas aeruginosa NOT SOLUTION NMR 99.5
4R0S HYDROLASE 08/01/14 Crystal structure of P. aeruginosa TpbA Pseudomonas aeruginosa PAO1 2.03 X-RAY DIFFRACTION 98.2
4R0T HYDROLASE 08/01/14 Crystal structure of P. aeruginosa TpbA (C132S) in complex with pTyr Pseudomonas aeruginosa PAO1 2.603 X-RAY DIFFRACTION 97.7

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 32 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001786 (406 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_13660
Search term: tpbA

Human Homologs

References

Connecting quorum sensing, c-di-GMP, pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885).
Ueda A, Wood TK
PLoS Pathog 2009 Jun;5(6):e1000483
PubMed ID: 19543378