Pseudomonas aeruginosa UCBPP-PA14, PA14_17180 (lpxD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_17180
Name
lpxD
Replicon chromosome
Genomic location 1473505 - 1474566 (+ strand)

Cross-References

RefSeq YP_789518.1
GI 116051643
Entrez 4383259
INSDC ABJ12879.1
NCBI Locus Tag PA14_17180
UniParc UPI000039612D
UniProtKB Acc Q02RB8
UniProtKB ID LPXD_PSEAB
UniRef100 UniRef100_Q02RB8
UniRef50 UniRef50_B0VMV2
UniRef90 UniRef90_B7V7U2

Product

Feature Type CDS
Coding Frame 1
Product Name
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -3.96
Kyte-Doolittle Hydrophobicity Value 0.178
Molecular Weight (kDa) 36.2
Isoelectric Point (pI) 6.23

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6UEC TRANSFERASE 09/20/19 Pseudomonas aeruginosa LpxD Complex Structure with Ligand Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 2.6 X-RAY DIFFRACTION 99.4
3PMO TRANSFERASE 11/17/10 The structure of LpxD from Pseudomonas aeruginosa at 1.3 A resolution Pseudomonas aeruginosa 1.3 X-RAY DIFFRACTION 99.4
6UED TRANSFERASE 09/20/19 Apo Pseudomonas aeruginosa LpxD Structure Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.55 X-RAY DIFFRACTION 99.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 411 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002028 (520 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_17180
Search term: lpxD

Human Homologs

References

Expression of the lipopolysaccharide biosynthesis gene lpxD affects biofilm formation of Pseudomonas aeruginosa.
Alshalchi SA, Anderson GG
Arch Microbiol 2015 Mar;197(2):135-45
PubMed ID: 25173672