Pseudomonas aeruginosa UCBPP-PA14, PA14_45960 (lasR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_45960
Name
lasR
Replicon chromosome
Genomic location 4085339 - 4086058 (- strand)
Transposon Mutants in orthologs 8 transposon mutants in orthologs

Cross-References

RefSeq YP_791822.1
GI 116049375
Entrez 4382864
INSDC ABJ10611.1
NCBI Locus Tag PA14_45960
UniParc UPI000012E231
UniProtKB Acc Q02JR4
UniProtKB ID Q02JR4_PSEAB
UniRef100 UniRef100_P25084
UniRef50 UniRef50_P25084
UniRef90 UniRef90_P25084

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator LasR
Synonyms
Evidence for Translation
Charge (pH 7) -1.68
Kyte-Doolittle Hydrophobicity Value -0.020
Molecular Weight (kDa) 26.6
Isoelectric Point (pI) 6.51

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3JPU TRANSCRIPTION 09/04/09 LasR-TP4 complex PSEUDOMONAS AERUGINOSA 2.3 X-RAY DIFFRACTION 100.0
6D6C signaling protein/agonist 04/20/18 The structure of ligand binding domain of LasR in complex with TP-1 homolog, compound 12 PSEUDOMONAS AERUGINOSA PAO1 1.88 X-RAY DIFFRACTION 100.0
3IX3 TRANSCRIPTION 09/03/09 LasR-OC12 HSL complex PSEUDOMONAS AERUGINOSA 1.4 X-RAY DIFFRACTION 100.0
2UV0 TRANSCRIPTION 03/08/07 Structure of the P. aeruginosa LasR ligand-binding domain bound to its autoinducer PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 100.0
3IX4 TRANSCRIPTION 09/03/09 LasR-TP1 complex PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 100.0
3IX8 TRANSCRIPTION 09/03/09 LasR-TP3 complex PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
N-3-OXO-DODECANOYL-L-HOMOSERINE LACTONE DB08324 DrugBank 5.1.1 P25084 Transcriptional activator protein LasR 100.0 239 1.7e-135

Virulence Evidence

Source 1
Database Victors : 4416
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Dictyostelium discoideum
Notes
Reference 11867744

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 142 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001096 (1475 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_45960
Search term: lasR

References

No references are associated with this feature.