Pseudomonas aeruginosa UCBPP-PA14, PA14_51340 (mvfR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_51340
Name
mvfR
Replicon chromosome
Genomic location 4562837 - 4563835 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq YP_792268.1
GI 116048931
Entrez 4379987
INSDC ABJ10167.1
NCBI Locus Tag PA14_51340
UniParc UPI0000E44B70
UniProtKB Acc Q02IG8
UniProtKB ID Q02IG8_PSEAB
UniRef100 UniRef100_Q02IG8
UniRef50 UniRef50_Q02IG8
UniRef90 UniRef90_Q02IG8

Product

Feature Type CDS
Coding Frame 1
Product Name
transcriptional regulator MvfR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 1.77
Kyte-Doolittle Hydrophobicity Value -0.131
Molecular Weight (kDa) 37.2
Isoelectric Point (pI) 7.56

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Membrane Class 1
cell fractionation evidence
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
4JVD TRANSCRIPTION REGULATOR 03/25/13 Crystal structure of PqsR coinducer binding domain of Pseudomonas aeruginosa with ligand NHQ PSEUDOMONAS AERUGINOSA 2.95 X-RAY DIFFRACTION 100.0
6B8A TRANSCRIPTION 10/05/17 Crystal structure of MvfR ligand binding domain in complex with M64 PSEUDOMONAS AERUGINOSA 2.65 X-RAY DIFFRACTION 100.0
4JVC TRANSCRIPTION REGULATOR 03/25/13 Crystal structure of PqsR co-inducer binding domain PSEUDOMONAS AERUGINOSA 2.5 X-RAY DIFFRACTION 100.0
4JVI TRANSCRIPTION REGULATOR/INHIBITOR 03/25/13 Crystal structure of PqsR co-inducer binding domain of Pseudomonas aeruginosa with inhibitor 3NH2-7Cl-C9QZN PSEUDOMONAS AERUGINOSA 2.9 X-RAY DIFFRACTION 100.0

Virulence Evidence

Source 1
Database Victors : 4399
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Mus musculus
Notes
Reference 9371831
Source 2
Database PseudoCAP
Category Phenazine biosynthesis
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model acute pulmonary Infection model
Infection model chronic pulmonary Infection model
Reference 15213173
Source 3
Database PseudoCAP
Category
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Mus musculus
Notes
Infection model Mouse thermal injury model.
Reference 11724939
Source 4
Database PseudoCAP
Category
Evidence ECO:0000315
mutant phenotype evidence used in manual assertion
Host Organism Arabidopsis thaliana
Notes
Infection model Arabidopsis leaf infiltration assay
Reference 11724939

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 139 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000966 (294 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_51340
Search term: mvfR

References

A quorum sensing-associated virulence gene of Pseudomonas aeruginosa encodes a LysR-like transcription regulator with a unique self-regulatory mechanism.
Cao H, Krishnan G, Goumnerov B, Tsongalis J, Tompkins R, Rahme LG
Proc. Natl. Acad. Sci. U.S.A. 2001 Dec;98(25):14613-8
PubMed ID: 11724939