Pseudomonas aeruginosa UCBPP-PA14, PA14_51380 (pqsE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14
Locus Tag
PA14_51380
Name
pqsE
Replicon chromosome
Genomic location 4566077 - 4566982 (- strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 3 transposon mutants in orthologs

Cross-References

RefSeq YP_792271.1
GI 116048928
Entrez 4379984
INSDC ABJ10164.1
NCBI Locus Tag PA14_51380
UniParc UPI0000139EE3
UniProtKB Acc Q02IG5
UniProtKB ID Q02IG5_PSEAB
UniRef100 UniRef100_P20581
UniRef50 UniRef50_P20581
UniRef90 UniRef90_P20581

Product

Feature Type CDS
Coding Frame 1
Product Name
quinolone signal response protein
Synonyms
Evidence for Translation
Charge (pH 7) -10.61
Kyte-Doolittle Hydrophobicity Value -0.178
Molecular Weight (kDa) 34.3
Isoelectric Point (pI) 5.25

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5HIS METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 3-methylthiophene-2-carboxylic acid PSEUDOMONAS AERUGINOSA PAO1 1.77 X-RAY DIFFRACTION 100.0
5HIP METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-(pyridin-3-yl)benzoic acid PSEUDOMONAS AERUGINOSA PAO1 1.992 X-RAY DIFFRACTION 100.0
2Q0I METAL BINDING PROTEIN 05/22/07 Structure of Pseudomonas Quinolone Signal Response Protein PqsE PSEUDOMONAS AERUGINOSA 1.57 X-RAY DIFFRACTION 100.0
5HIQ METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-(1H-pyrrol-1-yl)benzoic acid PSEUDOMONAS AERUGINOSA PAO1 2.1 X-RAY DIFFRACTION 100.0
2VW8 SIGNALING PROTEIN 06/17/08 Crystal Structure of Quinolone signal response protein pqsE from Pseudomonas aeruginosa PSEUDOMONAS AERUGINOSA PAO1 1.45 X-RAY DIFFRACTION 100.0
3DH8 METAL BINDING PROTEIN 06/17/08 Structure of Pseudomonas Quinolone Signal Response Protein PqsE PSEUDOMONAS AERUGINOSA 1.8 X-RAY DIFFRACTION 99.7
5HIO METAL BINDING PROTEIN 01/12/16 Crystal Structure of PQS Response Protein PqsE in Complex with 2-aminobenzoylacetate PSEUDOMONAS AERUGINOSA PAO1 1.9 X-RAY DIFFRACTION 100.0
2Q0J METAL BINDING PROTEIN 05/22/07 Structure of Pseudomonas Quinolone Signal Response Protein PqsE PSEUDOMONAS AERUGINOSA 2.1 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
bis(4-nitrophenyl) hydrogen phosphate DB07418 DrugBank 5.1.1 P20581 Uncharacterized protein PA1000 100.0 301 2.6e-178

Virulence Evidence

Source 1
Database PseudoCAP
Category
Evidence ECO:0000015
mutant phenotype evidence
Host Organism Caenorhabditis elegans
Notes
Infection model C. elegans slow killing assay.
Reference 22911607

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 100 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000963 (300 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_51380
Search term: pqsE

References

No references are associated with this feature.