Pseudomonas aeruginosa UCBPP-PA14, PA14_56790 (bifA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
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Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_56790
Name
bifA
Replicon chromosome
Genomic location 5058011 - 5060074 (+ strand)
Transposon Mutants 1 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq YP_792712.1
GI 116052401
Entrez 4382471
INSDC ABJ13637.1
NCBI Locus Tag PA14_56790
UniParc UPI00000C5CE4
UniProtKB Acc Q02H74
UniProtKB ID Q02H74_PSEAB
UniRef100 UniRef100_W0YZ94
UniRef50 UniRef50_D7I4A9
UniRef90 UniRef90_A0A0A8RHN1

Product

Feature Type CDS
Coding Frame 1
Product Name
BifA
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -11.51
Kyte-Doolittle Hydrophobicity Value -0.205
Molecular Weight (kDa) 77.5
Isoelectric Point (pI) 5.93

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
8ARV HYDROLASE 08/17/22 Structure of the EAL domain of BifA from Pseudomonas aeruginosa Pseudomonas aeruginosa PAO1 1.9 X-RAY DIFFRACTION 98.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 449 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003960 (524 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_56790
Search term: bifA
Search term: BifA

Human Homologs

References

BifA, a cyclic-Di-GMP phosphodiesterase, inversely regulates biofilm formation and swarming motility by Pseudomonas aeruginosa PA14.
Kuchma SL, Brothers KM, Merritt JH, Liberati NT, Ausubel FM, O'Toole GA
J Bacteriol 2007 Nov;189(22):8165-78
PubMed ID: 17586641