Pseudomonas aeruginosa UCBPP-PA14, PA14_57260 (lpxC)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_57260
Name	lpxC
Replicon	chromosome
Genomic location	5101834 - 5102745 (- strand)
Transposon Mutants	1 transposon mutants in UCBPP-PA14

Cross-References

RefSeq	YP_792752.1
GI	116052441
Entrez	4382511
INSDC	ABJ13677.1
NCBI Locus Tag	PA14_57260
UniParc	UPI0000396374
UniProtKB Acc	Q02H34
UniProtKB ID	LPXC_PSEAB
UniRef100	UniRef100_Q02H34
UniRef50	UniRef50_Q6D0I9
UniRef90	UniRef90_Q87WZ1

Product

Feature Type	CDS
Coding Frame	1
Product Name	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase
Synonyms
Evidence for Translation
Charge (pH 7)	-7.82
Kyte-Doolittle Hydrophobicity Value	-0.074
Molecular Weight (kDa)	33.5
Isoelectric Point (pI)	5.00

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
5DRR	hydrolase/hydrolase inhibitor	09/16/15	Crystal structure of the Pseudomonas aeruginosa LpxC/LPC-058 complex	Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)	1.59	X-RAY DIFFRACTION	99.3
7K99	HYDROLASE	09/28/20	Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.9	X-RAY DIFFRACTION	99.7
6MAE	HYDROLASE	08/27/18	CHAIN A. UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase PA-LPXC Complexed with (R)-3-((S)-3-(4-(cyclopropylethynyl)phenyl)-2-oxooxazolidin-5-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)propenamide	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.8	X-RAY DIFFRACTION	99.7
4LCF	HYDROLASE/ANTIBIOTIC	06/21/13	Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-014 complex	Pseudomonas aeruginosa	1.599	X-RAY DIFFRACTION	99.3
6CAX	hydrolase/hydrolase inhibitor	02/01/18	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT805	Pseudomonas aeruginosa	1.25	X-RAY DIFFRACTION	99.7
4FW7	HYDROLASE/HYDROLASE INHIBITOR	06/30/12	Crystal Structure of the LpxC in complex with N-[(2S,3R)-3-HYDROXY-1-(HYDROXYAMINO)-1-OXOBUTAN-2-YL]BIPHENYL-4-CARBOXAMIDE inhibitor	Pseudomonas aeruginosa	1.7	X-RAY DIFFRACTION	99.3
6MO5	HYDROLASE/INHIBITOR	10/04/18	Co-Crystal structure of P. aeruginosa LpxC-50228 complex	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.851	X-RAY DIFFRACTION	99.3
6C9C	hydrolase/hydrolase inhibitor	01/26/18	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with racemic ligand PT803	Pseudomonas aeruginosa (strain UCBPP-PA14)	2	X-RAY DIFFRACTION	99.7
5N8C	HYDROLASE	02/23/17	Crystal structure of Pseudomonas aeruginosa LpxC complexed with inhibitor	Pseudomonas aeruginosa	1.9	X-RAY DIFFRACTION	99.3
6DUI	hydrolase/hydrolase inhibitor	06/20/18	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PT801	Pseudomonas aeruginosa (strain LESB58)	1.55	X-RAY DIFFRACTION	99.7
5UPG	HYDROLASE	02/02/17	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with PF-5081090	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.7	X-RAY DIFFRACTION	99.7
8E4A	BIOSYNTHETIC PROTEIN	08/17/22	Pseudomonas LpxC in complex with LPC-233	Pseudomonas aeruginosa	2.034	X-RAY DIFFRACTION	99.3
4LCG	HYDROLASE/ANTIBIOTIC	06/21/13	Crystal structure of the Pseudomonas aeruginosa LPXC/LPC-050 complex	Pseudomonas aeruginosa	1.568	X-RAY DIFFRACTION	99.3
6MO4	HYDROLASE/INHIBITOR	10/04/18	Co-Crystal structure of P. aeruginosa LpxC-50067 complex	Pseudomonas aeruginosa PAO1	1.844	X-RAY DIFFRACTION	99.7
7K9A	HYDROLASE	09/29/20	Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2	X-RAY DIFFRACTION	99.7
5VWM	Hydrolase/Hydrolase Inhibitor	05/22/17	Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	1.8	X-RAY DIFFRACTION	99.7
5U3B	HYDROLASE	12/01/16	Pseudomonas aeruginosa LpxC in complex with NVS-LPXC-01	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2	X-RAY DIFFRACTION	99.7
7CID	HYDROLASE	07/07/20	Crystal structure of P.aeruginosa LpxC in complex with inhibitor	Pseudomonas aeruginosa PAO1	2.49	X-RAY DIFFRACTION	99.3
6MOD	HYDROLASE/INHIBITOR	10/04/18	Co-Crystal structure of P. aeruginosa LpxC-50432 complex	Pseudomonas aeruginosa	1.85	X-RAY DIFFRACTION	99.3
6E54	hydrolase/hydrolase inhibitor	07/19/18	Crystal structure of LpxC from Pseudomonas aeruginosa in complex with ligand PT802	Pseudomonas aeruginosa	1.65	X-RAY DIFFRACTION	99.7

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name	Source Accession	Source DB	Version	Target Accession	Target Description	Percent Identity	Alignment Length	E-Value
(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide	DB07861	DrugBank	5.1.4	P47205	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	99.7	303	1.9e-166

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 387 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG003996 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_57260 Search term: lpxC Search term: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Human Homologs

References