Pseudomonas aeruginosa UCBPP-PA14, PA14_57330 (murC)

Gene Feature Overview

Strain	Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006) GCF_000014625.1|latest
Locus Tag	PA14_57330
Name	murC
Replicon	chromosome
Genomic location	5107191 - 5108633 (- strand)

Cross-References

RefSeq	YP_792757.1
GI	116052445
EC Number	6.3.2.8
Entrez	4382515
INSDC	ABJ13681.1
NCBI Locus Tag	PA14_57330
UniParc	UPI000012F96B
UniProtKB Acc	Q02H29
UniProtKB ID	MURC_PSEAB
UniRef100	UniRef100_B7UZI9
UniRef50	UniRef50_Q87SG3
UniRef90	UniRef90_A6VB84

Product

Feature Type	CDS
Coding Frame	1
Product Name	UDP-N-acetylmuramate--L-alanine ligase
Synonyms
Evidence for Translation
Charge (pH 7)	-6.22
Kyte-Doolittle Hydrophobicity Value	0.013
Molecular Weight (kDa)	51.9
Isoelectric Point (pI)	6.10

Subcellular localization

Individual Mappings	Localization Confidence PMID Cytoplasmic Class 3 20472543
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession	Header	Accession Date	Compound	Source	Resolution	Method	Percent Identity
8EGM	LIGASE	09/12/22	Crystal Structure of UDP-N-acetylmuramate-L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase, MurC) Pseudomonas aeruginosa in complex with compound AZ13644908	Pseudomonas aeruginosa PAO1	2.2	X-RAY DIFFRACTION	100.0
5VVW	LIGASE	05/21/17	Structure of MurC from Pseudomonas aeruginosa	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.3	X-RAY DIFFRACTION	100.0
6X9F	LIGASE	06/02/20	Pseudomonas aeruginosa MurC with AZ8074	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.35	X-RAY DIFFRACTION	100.0
6X9N	LIGASE	06/03/20	Pseudomonas aeruginosa MurC with AZ5595	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	2.25	X-RAY DIFFRACTION	100.0
8DOF	LIGASE	07/13/22	Pseudomonas aeruginosa MurC with WYH9-2-P - OSA_001044	Pseudomonas aeruginosa	2.6	X-RAY DIFFRACTION	100.0

Pathogen Association Analysis

Results

Common Found in both pathogen and nonpathogenic strains Hits to this gene were found in 583 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database	View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group	POG004001 (535 members)
Putative Inparalogs	None Found

Interactions

STRING database

Search for predicted protein-protein interactions using: Search term: PA14_57330 Search term: murC Search term: UDP-N-acetylmuramate--L-alanine ligase

Human Homologs

References