Pseudomonas aeruginosa UCBPP-PA14, PA14_62580 (panB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_62580
Name
panB
Replicon chromosome
Genomic location 5583394 - 5584194 (+ strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_793193.1
GI 116052876
EC Number 2.1.2.11
Entrez 4383178
INSDC ABJ14112.1
NCBI Locus Tag PA14_62580
UniParc UPI0000396E5E
UniProtKB Acc Q02FU3
UniProtKB ID PANB2_PSEAB
UniRef100 UniRef100_Q02FU3
UniRef50 UniRef50_Q9JZW6
UniRef90 UniRef90_Q9HV70

Product

Feature Type CDS
Coding Frame 1
Product Name
3-methyl-2-oxobutanoate hydroxymethyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -5.20
Kyte-Doolittle Hydrophobicity Value 0.262
Molecular Weight (kDa) 27.8
Isoelectric Point (pI) 5.82

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
2-Dehydropantoate DB03795 DrugBank 5.1.4 P31057 3-methyl-2-oxobutanoate hydroxymethyltransferase 50.9 265 2.1e-68

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 533 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004376 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_62580
Search term: panB

Human Homologs

References

No references are associated with this feature.