Pseudomonas aeruginosa UCBPP-PA14, PA14_67350 (hutU)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_67350
Name
hutU
Replicon chromosome
Genomic location 6015332 - 6017011 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 4 transposon mutants in orthologs

Cross-References

RefSeq YP_793570.1
GI 116053247
EC Number 4.2.1.49
Entrez 4383412
INSDC ABJ14483.1
NCBI Locus Tag PA14_67350
UniParc UPI000045D515
UniProtKB Acc Q02ER6
UniProtKB ID HUTU_PSEAB
UniRef100 UniRef100_B7V3J3
UniRef50 UniRef50_P25080
UniRef90 UniRef90_Q9HU83

Product

Feature Type CDS
Coding Frame 1
Product Name
urocanate hydratase
Synonyms
Evidence for Translation
Charge (pH 7) -5.07
Kyte-Doolittle Hydrophobicity Value -0.248
Molecular Weight (kDa) 61.2
Isoelectric Point (pI) 6.33

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1UWL HYDROLASE 02/05/04 1.76A Structure of Urocanate Hydratase from Pseudomonas putida PSEUDOMONAS PUTIDA 1.76 X-RAY DIFFRACTION 91.5
2V7G LYASE 07/30/07 Crystal Structure of an Engineered Urocanase Tetramer PSEUDOMONAS PUTIDA 2 X-RAY DIFFRACTION 91.4
1UWK HYDROLASE 02/05/04 The High Resolution Structure of Urocanate Hydratase from Pseudomonas putida in complex with urocanate PSEUDOMONAS PUTIDA 1.19 X-RAY DIFFRACTION 91.4
1W1U HYDROLASE 06/24/04 Inactive Urocanase-SA cocrystallized with urocanate PSEUDOMONAS PUTIDA 2.23 X-RAY DIFFRACTION 91.4

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 266 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004696 (504 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_67350
Search term: hutU

Human Homologs

Ensembl 110, assembly GRCh38.p14
urocanate hydratase 1 [Source:HGNC Symbol;Acc:HGNC:26444]
E-value: 7.2e-84
Percent Identity: 33.4

References

No references are associated with this feature.