Pseudomonas aeruginosa UCBPP-PA14, PA14_67510 (estA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_67510
Name
estA
Replicon chromosome
Genomic location 6026551 - 6028491 (- strand)
Transposon Mutants 2 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 8 transposon mutants in orthologs

Cross-References

RefSeq YP_793582.1
GI 116053259
Entrez 4383424
INSDC ABJ14495.1
NCBI Locus Tag PA14_67510
UniParc UPI00000D426D
UniProtKB Acc Q02EQ4
UniProtKB ID Q02EQ4_PSEAB
UniRef100 UniRef100_O33407
UniRef50 UniRef50_O33407
UniRef90 UniRef90_O33407

Product

Feature Type CDS
Coding Frame 1
Product Name
esterase EstA
Synonyms
Evidence for Translation
Charge (pH 7) -21.63
Kyte-Doolittle Hydrophobicity Value -0.375
Molecular Weight (kDa) 69.6
Isoelectric Point (pI) 4.46

Subcellular localization

Individual Mappings
Localization Confidence PMID
Outer Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3KVN HYDROLASE 11/30/09 Crystal structure of the full-length autotransporter EstA from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.499 X-RAY DIFFRACTION 100.0

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
(Hydroxyethyloxy)Tri(Ethyloxy)Octane DB04233 DrugBank 5.1.4 O33407 Esterase EstA 100.0 646 0.0e+00

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 92 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004538 (814 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_67510
Search term: estA
Search term: esterase EstA

Human Homologs

References

No references are associated with this feature.