Pseudomonas aeruginosa UCBPP-PA14, PA14_69440 (hemD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_69440
Name
hemD
Replicon chromosome
Genomic location 6192956 - 6193711 (- strand)

Cross-References

RefSeq YP_793732.1
GI 116053407
EC Number 4.2.1.75
Entrez 4384481
INSDC ABJ14643.1
NCBI Locus Tag PA14_69440
UniParc UPI000012C4A8
UniProtKB Acc Q02EA4
UniProtKB ID Q02EA4_PSEAB
UniRef100 UniRef100_P48246
UniRef50 UniRef50_P48246
UniRef90 UniRef90_P48246

Product

Feature Type CDS
Coding Frame 1
Product Name
uroporphyrinogen-III synthase
Synonyms
Evidence for Translation
Charge (pH 7) -6.64
Kyte-Doolittle Hydrophobicity Value -0.053
Molecular Weight (kDa) 27.2
Isoelectric Point (pI) 4.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
6TH8 FLAVOPROTEIN 11/19/19 Reconstructing the Origins of the HemD-like fold Thermus thermophilus NOT SOLUTION NMR 94.7
4ES6 LYASE 04/22/12 Crystal structure of HemD (PA5259) from Pseudomonas aeruginosa (PAO1) at 2.22 A resolution Pseudomonas aeruginosa 2.22 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 192 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004840 (518 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_69440
Search term: hemD

Human Homologs

References

No references are associated with this feature.