Pseudomonas aeruginosa UCBPP-PA14, PA14_69990 (dadX)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_69990
Name
dadX
Replicon chromosome
Genomic location 6243935 - 6245008 (- strand)
Transposon Mutants 4 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq YP_793776.1
GI 116053449
EC Number 5.1.1.1
Entrez 4385183
INSDC ABJ14685.1
NCBI Locus Tag PA14_69990
UniParc UPI000045D565
UniProtKB Acc Q02E60
UniProtKB ID Q02E60_PSEAB
UniRef100 UniRef100_Q02E60
UniRef50 UniRef50_Q9HTQ2
UniRef90 UniRef90_Q9HTQ2

Product

Feature Type CDS
Coding Frame 1
Product Name
alanine racemase
Synonyms
Evidence for Translation
Charge (pH 7) 0.23
Kyte-Doolittle Hydrophobicity Value -0.005
Molecular Weight (kDa) 39.0
Isoelectric Point (pI) 7.05

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1RCQ ISOMERASE 11/04/03 The 1.45 A crystal structure of alanine racemase from a pathogenic bacterium, Pseudomonas aeruginosa, contains both internal and external aldimine forms Pseudomonas aeruginosa 1.45 X-RAY DIFFRACTION 99.4

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
Lysine Nz-Carboxylic Acid DB03801 DrugBank 5.1.4 Q9HTQ2 Alanine racemase, catabolic 99.7 357 5.4e-205
D-Lysine DB03252 DrugBank 5.1.4 Q9HTQ2 Alanine racemase, catabolic 99.7 357 5.4e-205

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 560 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004545 (850 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_69990
Search term: dadX
Search term: alanine racemase

Human Homologs

References

No references are associated with this feature.