Pseudomonas aeruginosa UCBPP-PA14, PA14_70370 (pyrE)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse

Gene Feature Overview

Strain Pseudomonas aeruginosa UCBPP-PA14 (Lee et al., 2006)
GCF_000014625.1|latest
Locus Tag
PA14_70370
Name
pyrE
Replicon chromosome
Genomic location 6274318 - 6274959 (- strand)
Transposon Mutants 3 transposon mutants in UCBPP-PA14
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq YP_793805.1
GI 116053478
EC Number 2.4.2.10
Entrez 4385094
INSDC ABJ14714.1
NCBI Locus Tag PA14_70370
UniParc UPI0000132CCD
UniProtKB Acc Q02E31
UniProtKB ID PYRE_PSEAB
UniRef100 UniRef100_Q02E31
UniRef50 UniRef50_O94331
UniRef90 UniRef90_Q02E31

Product

Feature Type CDS
Coding Frame 1
Product Name
orotate phosphoribosyltransferase
Synonyms
Evidence for Translation
Charge (pH 7) -4.31
Kyte-Doolittle Hydrophobicity Value 0.043
Molecular Weight (kDa) 23.3
Isoelectric Point (pI) 5.12

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Drugs Targeting this Protein

Identified by Diamond using e-value cutoff of 0.0001 and returning alignments that span 100% of the query sequence and that have more than 95% identity.

Drug Name Source Accession Source DB Version Target Accession Target Description Percent Identity Alignment Length E-Value
5-O-phosphono-alpha-D-ribofuranosyl diphosphate DB01632 DrugBank 5.1.4 P08870 Orotate phosphoribosyltransferase 69.0 213 3.5e-82
Orotic Acid DB02262 DrugBank 5.1.4 P08870 Orotate phosphoribosyltransferase 69.0 213 3.5e-82

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 357 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG004900 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA14_70370
Search term: pyrE

Human Homologs

References

No references are associated with this feature.