Pseudomonas aeruginosa PAO1, PA3620 (mutS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3620
Name
mutS
Synonym: fdv
Replicon chromosome
Genomic location 4054525 - 4057092 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252310.1
GI 15598816
Affymetrix PA3620_mutS_at
Entrez 880229
GenBank AAG07008.1
INSDC AAG07008.1
NCBI Locus Tag PA3620
protein_id(GenBank) gb|AAG07008.1|AE004782_6|gnl|PseudoCAP|PA3620
TIGR NTL03PA03620
UniParc UPI00000C5A97
UniProtKB Acc Q9HY08
UniProtKB ID MUTS_PSEAE
UniRef100 UniRef100_Q9HY08
UniRef50 UniRef50_Q9S6P8
UniRef90 UniRef90_A6V1G8

Product

Feature Type CDS
Coding Frame 1
Product Name
DNA mismatch repair protein MutS
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -11.64
Kyte-Doolittle Hydrophobicity Value -0.226
Molecular Weight (kDa) 95.0
Isoelectric Point (pI) 6.13

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 548 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002054 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3620
Search term: mutS

Human Homologs

Ensembl 110, assembly GRCh38.p14
mutS homolog 3 [Source:HGNC Symbol;Acc:HGNC:7326]
E-value: 3.8e-68
Percent Identity: 27.6
Ensembl 110, assembly GRCh38.p14
mutS homolog 3 [Source:HGNC Symbol;Acc:HGNC:7326]
E-value: 3.8e-68
Percent Identity: 27.6

References

The Escherichia coli fdv gene probably encodes mutS and is located at minute 58.8 adjacent to the hyc-hyp gene cluster.
Schlensog V, Böck A
J Bacteriol 1991 Dec;173(23):7414-5
PubMed ID: 1938937
Azotobacter vinelandii mutS: nucleotide sequence and mutant analysis.
Le O, Shen B, Iismaa SE, Burgess BK
J Bacteriol 1993 Dec;175(23):7707-10
PubMed ID: 8244942