Pseudomonas aeruginosa PAO1, PA3630 (gfnR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3630
Name
gfnR
Replicon chromosome
Genomic location 4065119 - 4066027 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252320.1
GI 15598826
Affymetrix PA3630_at
DNASU PaCD00007592
Entrez 880466
GenBank AAG07018.1
INSDC AAG07018.1
NCBI Locus Tag PA3630
protein_id(GenBank) gb|AAG07018.1|AE004783_3|gnl|PseudoCAP|PA3630
TIGR NTL03PA03630
UniParc UPI00000C5A9C
UniProtKB Acc Q9HY00
UniProtKB ID Q9HY00_PSEAE
UniRef100 UniRef100_Q9HY00
UniRef50 UniRef50_A9L4A5
UniRef90 UniRef90_Q9HY00

Product

Feature Type CDS
Coding Frame 1
Product Name
glutathione-dependent formaldehyde neutralization regulator GfnR
Product Name Confidence: Class 1
Synonyms probable transcriptional regulator
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 3.98
Kyte-Doolittle Hydrophobicity Value -0.346
Molecular Weight (kDa) 34.1
Isoelectric Point (pI) 8.14

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 490 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002044 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3630
Search term: gfnR

Human Homologs

References

Sarcosine Catabolism in Pseudomonas aeruginosa Is Transcriptionally Regulated by SouR.
Willsey GG, Wargo MJ
J Bacteriol 2016 Jan 15;198(2):301-10
PubMed ID: 26503852