Pseudomonas aeruginosa PAO1, PA3664

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3664
Name
Synonym: yffB
Replicon chromosome
Genomic location 4103732 - 4104079 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252354.1
GI 15598860
Affymetrix PA3664_at
Entrez 880544
GenBank AAG07052.1
INSDC AAG07052.1
NCBI Locus Tag PA3664
protein_id(GenBank) gb|AAG07052.1|AE004786_4|gnl|PseudoCAP|PA3664
TIGR NTL03PA03664
UniParc UPI00000C5AAB
UniProtKB Acc Q9HXX5
UniProtKB ID Q9HXX5_PSEAE
UniRef100 UniRef100_Q9HXX5
UniRef50 UniRef50_Q9HXX5
UniRef90 UniRef90_Q9HXX5

Product

Feature Type CDS
Coding Frame 1
Product Name
putative glutathione-dependent thiol reductase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 2.89
Kyte-Doolittle Hydrophobicity Value -0.363
Molecular Weight (kDa) 13.1
Isoelectric Point (pI) 8.69

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
1RW1 STRUCTURAL GENOMICS, UNKNOWN FUNCTION 12/15/03 YFFB (PA3664) PROTEIN Pseudomonas aeruginosa 1.02 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 279 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG002010 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3664

Human Homologs

References

Crystal structure of the YffB protein from Pseudomonas aeruginosa suggests a glutathione-dependent thiol reductase function.
Teplyakov A, Pullalarevu S, Obmolova G, Doseeva V, Galkin A, Herzberg O, Dauter M, Dauter Z, Gilliland GL
BMC Struct Biol 2004 Mar 8;4:5
PubMed ID: 15102337
Solution structure of an arsenate reductase-related protein, YffB, from Brucella melitensis, the etiological agent responsible for brucellosis.
Buchko GW, Hewitt SN, Napuli AJ, Van Voorhis WC, Myler PJ
Acta Crystallogr Sect F Struct Biol Cryst Commun 2011 Sep 1;67(Pt 9):1129-36
PubMed ID: 21904062