Strain |
Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest |
Locus Tag |
PA3678
|
Name |
mexL
|
Replicon | chromosome |
Genomic location | 4120469 - 4121107 (+ strand) |
Transposon Mutants | 1 transposon mutants in PAO1 |
Transposon Mutants in orthologs | 2 transposon mutants in orthologs |
RefSeq | NP_252368.1 |
GI | 15598874 |
Affymetrix | PA3678_at |
Entrez | 880594 |
GenBank | AAG07066.1 |
INSDC | AAG07066.1 |
NCBI Locus Tag | PA3678 |
protein_id(GenBank) | gb|AAG07066.1|AE004787_6|gnl|PseudoCAP|PA3678 |
TIGR | NTL03PA03678 |
UniParc | UPI00000C5AB6 |
UniProtKB Acc | Q9HXW2 |
UniProtKB ID | Q9HXW2_PSEAE |
UniRef100 | UniRef100_W0YWF3 |
UniRef50 | UniRef50_A6V1B0 |
UniRef90 | UniRef90_A6V1B0 |
Feature Type | CDS |
Coding Frame | 1 |
Product Name |
MexL
|
Synonyms | |
Evidence for Translation |
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
|
Charge (pH 7) | -2.68 |
Kyte-Doolittle Hydrophobicity Value | -0.117 |
Molecular Weight (kDa) | 23.2 |
Isoelectric Point (pI) | 6.25 |
Individual Mappings | |
Additional evidence for subcellular localization |
Identified using the Resistance Gene Identifier (RGI)
Model Name | Definition | Accession | Model Type (?) | SNP | Cutoff | Bit Score | Percent Identity | CARD Version |
MexL | MexL is a specific repressor of mexJK transcription and autoregulates its own expression. [PMID:15855505] | ARO:3003710 | protein homolog model | Perfect | 417.5 | 100.0 | 3.2.5 |
Results |
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 370 genera
|
Pseudomonas Ortholog Database | View orthologs at Pseudomonas Ortholog Database |
Pseudomonas Ortholog Group |
POG001962 (826 members) |
Putative Inparalogs | None Found |
STRING database | Search for predicted protein-protein interactions using:
Search term: PA3678
Search term: mexL
Search term: MexL
|
The MexJK efflux pump of Pseudomonas aeruginosa requires OprM for antibiotic efflux but not for efflux of triclosan.
Chuanchuen R, Narasaki CT, Schweizer HP
J Bacteriol 2002 Sep;184(18):5036-44
PubMed ID: 12193619
|
Molecular characterization of MexL, the transcriptional repressor of the mexJK multidrug efflux operon in Pseudomonas aeruginosa.
Chuanchuen R, Gaynor JB, Karkhoff-Schweizer R, Schweizer HP
Antimicrob Agents Chemother 2005 May;49(5):1844-51
PubMed ID: 15855505
|