Pseudomonas aeruginosa PAO1, PA3719 (armR)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3719
Name
armR
Replicon chromosome
Genomic location 4165719 - 4165880 (- strand)
Transposon Mutants 1 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentArmR is an antirepressor for MexR

Cross-References

RefSeq NP_252408.1
GI 15598914
Affymetrix PA3719_at
Entrez 880376
GenBank AAG07106.1
INSDC AAG07106.1
NCBI Locus Tag PA3719
protein_id(GenBank) gb|AAG07106.1|AE004791_3|gnl|PseudoCAP|PA3719
TIGR NTL03PA03719
UniParc UPI00000C5ADA
UniProtKB Acc Q9HXS2
UniProtKB ID Q9HXS2_PSEAE
UniRef100 UniRef100_W0YX37
UniRef50 UniRef50_W0YX37
UniRef90 UniRef90_W0YX37

Product

Feature Type CDS
Coding Frame 1
Product Name
antirepressor for MexR, ArmR
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 4.22
Kyte-Doolittle Hydrophobicity Value -1.160
Molecular Weight (kDa) 6.1
Isoelectric Point (pI) 10.72

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
ArmR ArmR, a 53-amino-acid antirepressor, allosterically inhibits MexR dimer-DNA binding by occupying a hydrophobic binding cavity within the center of the MexR dimer. ArmR up-regulation and MexR-ArmR complex formation have previously been shown to upregulate MexAB-OprM. [PMID:17545281, PMID:18812515] ARO:3004056 protein homolog model Perfect 106.3 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3ECH Transcription, Transcription regulation 08/30/08 The MarR-family repressor MexR in complex with its antirepressor ArmR Pseudomonas aeruginosa 1.802 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in one genus

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001964 (205 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3719
Search term: armR

Human Homologs

References

Protein modulator of multidrug efflux gene expression in Pseudomonas aeruginosa.
Daigle DM, Cao L, Fraud S, Wilke MS, Pacey A, Klinoski R, Strynadka NC, Dean CR, Poole K
J Bacteriol 2007 Aug;189(15):5441-51
PubMed ID: 17545281