Pseudomonas aeruginosa PAO1, PA3753

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3753
Name
Synonym: fbp
Replicon chromosome
Genomic location 4204734 - 4205258 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252442.1
GI 15598948
Affymetrix PA3753_at
DNASU PaCD00007635
Entrez 880438
GenBank AAG07140.1
INSDC AAG07140.1
NCBI Locus Tag PA3753
protein_id(GenBank) gb|AAG07140.1|AE004794_5|gnl|PseudoCAP|PA3753
TIGR NTL03PA03753
UniParc UPI0000139451
UniProtKB Acc P40882
UniProtKB ID Y3753_PSEAE
UniRef100 UniRef100_P40882
UniRef50 UniRef50_P40882
UniRef90 UniRef90_P40882

Product

Feature Type CDS
Coding Frame 1
Product Name
conserved hypothetical protein
Product Name Confidence: Class 4
Synonyms ferripyochelin binding protein
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -0.15
Kyte-Doolittle Hydrophobicity Value -0.066
Molecular Weight (kDa) 18.5
Isoelectric Point (pI) 6.96

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Cytoplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 525 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001929 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3753

Human Homologs

References

Subinhibitory concentrations of tetracycline inhibit surface expression of the Pseudomonas aeruginosa ferripyochelin binding protein in vivo.
LeVatte MA, Woods DE, Shahrabadi MS, Semple R, Sokol PA
J Antimicrob Chemother 1990 Aug;26(2):215-25
PubMed ID: 2120176
Pyochelin-mediated iron transport in Pseudomonas aeruginosa: involvement of a high-molecular-mass outer membrane protein.
Heinrichs DE, Young L, Poole K
Infect Immun 1991 Oct;59(10):3680-4
PubMed ID: 1910015
Localization of the virulence-associated genes pilA, pilR, rpoN, fliA, fliC, ent, and fbp on the physical map of Pseudomonas aeruginosa PAO1 by pulsed-field electrophoresis.
Farinha MA, Ronald SL, Kropinski AM, Paranchych W
Infect Immun 1993 Apr;61(4):1571-5
PubMed ID: 8454366