Pseudomonas aeruginosa PAO1, PA3787

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3787
Name
Replicon chromosome
Genomic location 4244876 - 4245724 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252476.1
GI 15598982
Affymetrix PA3787_at
DNASU PaCD00007650
Entrez 880585
GenBank AAG07174.1
INSDC AAG07174.1
NCBI Locus Tag PA3787
protein_id(GenBank) gb|AAG07174.1|AE004797_9|gnl|PseudoCAP|PA3787
TIGR NTL03PA03787
UniParc UPI00000C5B12
UniProtKB Acc Q9HXK8
UniProtKB ID Q9HXK8_PSEAE
UniRef100 UniRef100_W0YWV5
UniRef50 UniRef50_A0A0B7DHF2
UniRef90 UniRef90_A6V0X7

Product

Feature Type CDS
Coding Frame 1
Product Name
putative peptidase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 12.62
Kyte-Doolittle Hydrophobicity Value -0.183
Molecular Weight (kDa) 30.8
Isoelectric Point (pI) 10.50

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
2HSI STRUCTURAL GENOMICS, UNKNOWN FUNCTION 07/21/06 Crystal structure of putative peptidase M23 from pseudomonas aeruginosa, New York Structural Genomics Consortium Pseudomonas aeruginosa PAO1 1.9 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 521 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001879 (535 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3787

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The C-terminus of substrates is critical but not sufficient for their degradation by the Pseudomonas aeruginosa CtpA protease.
Chung S, Darwin AJ
J Bacteriol 2020 Jun 1;202(16)
PubMed ID: 32482720
A Proteolytic Complex Targets Multiple Cell Wall Hydrolases in Pseudomonas aeruginosa.
Srivastava D, Seo J, Rimal B, Kim SJ, Zhen S, Darwin AJ
mBio 2018 Jul 17;9(4)
PubMed ID: 30018106