Pseudomonas aeruginosa PAO1, PA3827 (lptG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3827
Name
lptG
Synonym: yjgQ
Replicon chromosome
Genomic location 4284417 - 4285484 (- strand)

Cross-References

RefSeq NP_252516.1
GI 15599022
Affymetrix PA3827_at
Entrez 879872
GenBank AAG07214.1
INSDC AAG07214.1
NCBI Locus Tag PA3827
protein_id(GenBank) gb|AAG07214.1|AE004800_3|gnl|PseudoCAP|PA3827
TIGR NTL03PA03827
UniParc UPI00000C5B2C
UniProtKB Acc Q9HXH5
UniProtKB ID Q9HXH5_PSEAE
UniRef100 UniRef100_Q9HXH5
UniRef50 UniRef50_E2XM53
UniRef90 UniRef90_Q9HXH5

Product

Feature Type CDS
Coding Frame 1
Product Name
Lipopolysaccharide export system permease protein LptG
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 5.14
Kyte-Doolittle Hydrophobicity Value 0.427
Molecular Weight (kDa) 39.2
Isoelectric Point (pI) 9.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5X5Y MEMBRANE PROTEIN 02/18/17 A membrane protein complex Pseudomonas aeruginosa PAO1 3.465 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 259 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001838 (534 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3827
Search term: lptG

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Proc Natl Acad Sci U S A 2008 Apr 8;105(14):5537-42
PubMed ID: 18375759