Pseudomonas aeruginosa PAO1, PA3862 (dauB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3862
Name
dauB
Replicon chromosome
Genomic location 4322788 - 4323735 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252551.1
GI 15599057
Affymetrix PA3862_at
Entrez 879805
GenBank AAG07249.1
INSDC AAG07249.1
NCBI Locus Tag PA3862
protein_id(GenBank) gb|AAG07249.1|AE004803_5|gnl|PseudoCAP|PA3862
TIGR NTL03PA03862
UniParc UPI00000C5B4A
UniProtKB Acc Q9HXE4
UniProtKB ID Q9HXE4_PSEAE
UniRef100 UniRef100_Q9HXE4
UniRef50 UniRef50_A0A0B7D7D6
UniRef90 UniRef90_A0A022NSH8

Product

Feature Type CDS
Coding Frame 1
Product Name
NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB
Product Name Confidence: Class 4
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -4.71
Kyte-Doolittle Hydrophobicity Value 0.032
Molecular Weight (kDa) 33.9
Isoelectric Point (pI) 5.66

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 218 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001807 (773 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3862
Search term: dauB

Human Homologs

References

Ornithine cyclodeaminase from Ti plasmid C58: DNA sequence, enzyme properties and regulation of activity by arginine.
Sans N, Schindler U, Schröder J
Eur J Biochem 1988 Apr 5;173(1):123-30
PubMed ID: 3281832
mu-crystallin is a mammalian homologue of Agrobacterium ornithine cyclodeaminase and is expressed in human retina.
Kim RY, Gasser R, Wistow GJ
Proc Natl Acad Sci U S A 1992 Oct 1;89(19):9292-6
PubMed ID: 1384048
Arginine racemization by coupled catabolic and anabolic dehydrogenases.
Li C, Lu CD
Proc Natl Acad Sci U S A 2009 Jan 20;106(3):906-11
PubMed ID: 19139398