Pseudomonas aeruginosa PAO1, PA3887 (nhaP)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3887
Name
nhaP
Replicon chromosome
Genomic location 4352828 - 4354102 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252576.1
GI 15599082
Affymetrix PA3887_nhaP_at
Entrez 878773
GenBank AAG07274.1
INSDC AAG07274.1
NCBI Locus Tag PA3887
protein_id(GenBank) gb|AAG07274.1|AE004806_1|gnl|PseudoCAP|PA3887
TIGR NTL03PA03887
UniParc UPI00000D4259
UniProtKB Acc G3XD29
UniProtKB ID NHAP_PSEAE
UniRef100 UniRef100_G3XD29
UniRef50 UniRef50_G3XD29
UniRef90 UniRef90_G3XD29

Product

Feature Type CDS
Coding Frame 1
Product Name
Na+/H+ antiporter NhaP
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.59
Kyte-Doolittle Hydrophobicity Value 0.966
Molecular Weight (kDa) 45.5
Isoelectric Point (pI) 6.52

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 358 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001783 (475 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3887
Search term: nhaP

Human Homologs

Ensembl 110, assembly GRCh38.p14
solute carrier family 9 member A5 [Source:HGNC Symbol;Acc:HGNC:11078]
E-value: 9.6e-12
Percent Identity: 29.0

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Cloning and sequencing of a novel Na+/H+ antiporter gene from Pseudomonas aeruginosa.
Utsugi J, Inaba K, Kuroda T, Tsuda M, Tsuchiya T
Biochim Biophys Acta 1998 Jul 9;1398(3):330-4
PubMed ID: 9655928