Pseudomonas aeruginosa PAO1, PA3888 (opuCD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA3888
Name
opuCD
Replicon chromosome
Genomic location 4354544 - 4355266 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs
CommentBroad-spectrum QAC-transporter activated by hyperosmolarity
CommentBroad-spectrum QAC-transporter activated by hyperosmolarity

Cross-References

RefSeq NP_252577.1
GI 15599083
Affymetrix PA3888_at
DNASU PaCD00007693
Entrez 878804
GenBank AAG07275.1
INSDC AAG07275.1
NCBI Locus Tag PA3888
protein_id(GenBank) gb|AAG07275.1|AE004806_2|gnl|PseudoCAP|PA3888
TIGR NTL03PA03888
UniParc UPI00000C5B5C
UniProtKB Acc Q9HXC5
UniProtKB ID Q9HXC5_PSEAE
UniRef100 UniRef100_A0A072ZD71
UniRef50 UniRef50_C9Y4Y7
UniRef90 UniRef90_A6V0L8

Product

Feature Type CDS
Coding Frame 1
Product Name
OpuC ABC transporter, permease protein, OpuCD
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 4.85
Kyte-Doolittle Hydrophobicity Value 1.012
Molecular Weight (kDa) 25.1
Isoelectric Point (pI) 9.26

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 429 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001782 (492 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA3888
Search term: opuCD

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Characterization of a chimeric proU operon in a subtilin-producing mutant of Bacillus subtilis 168.
Lin Y, Hansen JN
J Bacteriol 1995 Dec;177(23):6874-80
PubMed ID: 7592481
Characterization of the osmoprotectant transporter OpuC from Pseudomonas syringae and demonstration that cystathionine-beta-synthase domains are required for its osmoregulatory function.
Chen C, Beattie GA
J Bacteriol 2007 Oct;189(19):6901-12
PubMed ID: 17660277