Pseudomonas aeruginosa PAO1, PA4050 (pgpA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4050
Name
pgpA
Replicon chromosome
Genomic location 4532145 - 4532660 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252739.1
GI 15599245
Affymetrix PA4050_pgpA_at
DNASU PaCD00007770
Entrez 879074
GenBank AAG07437.1
INSDC AAG07437.1
NCBI Locus Tag PA4050
protein_id(GenBank) gb|AAG07437.1|AE004821_10|gnl|PseudoCAP|PA4050
TIGR NTL03PA04050
UniParc UPI00000C5BDF
UniProtKB Acc Q9HWX8
UniProtKB ID Q9HWX8_PSEAE
UniRef100 UniRef100_Q9HWX8
UniRef50 UniRef50_P18200
UniRef90 UniRef90_Q9HWX8

Product

Feature Type CDS
Coding Frame 1
Product Name
phosphatidylglycerophosphatase A
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.60
Kyte-Doolittle Hydrophobicity Value 0.507
Molecular Weight (kDa) 19.6
Isoelectric Point (pI) 5.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 242 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001634 (466 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4050
Search term: pgpA

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Multiple genes for membrane-bound phosphatases in Escherichia coli and their action on phospholipid precursors.
Icho T, Raetz CR
J Bacteriol 1983 Feb;153(2):722-30
PubMed ID: 6296050
Membrane-bound phosphatases in Escherichia coli: sequence of the pgpA gene.
Icho T
J Bacteriol 1988 Nov;170(11):5110-6
PubMed ID: 2846510
The pgpA and pgpB genes of Escherichia coli are not essential: evidence for a third phosphatidylglycerophosphate phosphatase.
Funk CR, Zimniak L, Dowhan W
J Bacteriol 1992 Jan;174(1):205-13
PubMed ID: 1309518