Pseudomonas aeruginosa PAO1, PA4051 (thiL)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4051
Name
thiL
Replicon chromosome
Genomic location 4532653 - 4533621 (- strand)

Cross-References

RefSeq NP_252740.1
GI 15599246
Affymetrix PA4051_thiL_at
Entrez 878642
GenBank AAG07438.1
INSDC AAG07438.1
NCBI Locus Tag PA4051
protein_id(GenBank) gb|AAG07438.1|AE004821_11|gnl|PseudoCAP|PA4051
TIGR NTL03PA04051
UniParc UPI00000C5BE0
UniProtKB Acc Q9HWX7
UniProtKB ID Q9HWX7_PSEAE
UniRef100 UniRef100_Q9HWX7
UniRef50 UniRef50_Q9HWX7
UniRef90 UniRef90_Q9HWX7

Product

Feature Type CDS
Coding Frame 1
Product Name
thiamine monophosphate kinase
Product Name Confidence: Class 2
Synonyms thiamin-phosphate kinase
Evidence for Translation
Charge (pH 7) -13.25
Kyte-Doolittle Hydrophobicity Value 0.381
Molecular Weight (kDa) 32.9
Isoelectric Point (pI) 4.41

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7DU3 PROTEIN BINDING 01/07/21 ThiL in complex with AMP-PNP Pseudomonas aeruginosa 2.54 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 535 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001633 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4051
Search term: thiL

Human Homologs

References

thiK and thiL loci of Escherichia coli.
Imamura N, Nakayama H
J Bacteriol 1982 Aug;151(2):708-17
PubMed ID: 6284709
Characterization of thiL, encoding thiamin-monophosphate kinase, in Salmonella typhimurium.
Webb E, Downs D
J Biol Chem 1997 Jun 20;272(25):15702-7
PubMed ID: 9188462
The complete genome sequence of Escherichia coli K-12.
Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y
Science 1997 Sep 5;277(5331):1453-62
PubMed ID: 9278503