Pseudomonas aeruginosa PAO1, PA4081 (cupB6)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4081
Name
cupB6
Replicon chromosome
Genomic location 4560295 - 4561440 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 5 transposon mutants in orthologs

Cross-References

RefSeq NP_252770.1
GI 15599276
Affymetrix PA4081_at
Entrez 878668
GenBank AAG07468.1
INSDC AAG07468.1
NCBI Locus Tag PA4081
protein_id(GenBank) gb|AAG07468.1|AE004824_3|gnl|PseudoCAP|PA4081
TIGR NTL03PA04081
UniParc UPI00000C5BFB
UniProtKB Acc Q9HWU7
UniProtKB ID Q9HWU7_PSEAE
UniRef100 UniRef100_Q9HWU7
UniRef50 UniRef50_Q9HWU7
UniRef90 UniRef90_Q9HWU7

Product

Feature Type CDS
Coding Frame 1
Product Name
fimbrial subunit CupB6
Product Name Confidence: Class 2
Synonyms probable fimbrial protein
Evidence for Translation
Charge (pH 7) 6.30
Kyte-Doolittle Hydrophobicity Value -0.070
Molecular Weight (kDa) 40.2
Isoelectric Point (pI) 8.94

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5CYL CELL ADHESION 07/30/15 Crystal structure of the CupB6 tip adhesin from Pseudomonas aeruginosa Pseudomonas aeruginosa 2.77 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 4 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000955 (1577 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4081
Search term: cupB6

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295