Pseudomonas aeruginosa PAO1, PA4088

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4088
Name
Replicon chromosome
Genomic location 4570929 - 4572314 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 4 transposon mutants in orthologs
Comment

Cross-References

RefSeq NP_252777.1
GI 15599283
Affymetrix PA4088_at
Entrez 878742
GenBank AAG07475.1
INSDC AAG07475.1
NCBI Locus Tag PA4088
protein_id(GenBank) gb|AAG07475.1|AE004825_4|gnl|PseudoCAP|PA4088
TIGR NTL03PA04088
UniParc UPI00000C5C02
UniProtKB Acc Q9HWU0
UniProtKB ID Q9HWU0_PSEAE
UniRef100 UniRef100_Q9HWU0
UniRef50 UniRef50_A9AL68
UniRef90 UniRef90_Q9HWU0

Product

Feature Type CDS
Coding Frame 1
Product Name
glutamate-1-semialdehyde aminomutase
Product Name Confidence: Class 1
Synonyms probable aminotransferase
Evidence for Translation
Charge (pH 7) -2.97
Kyte-Doolittle Hydrophobicity Value -0.139
Molecular Weight (kDa) 51.0
Isoelectric Point (pI) 6.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
5YKR TRANSFERASE 10/16/17 Crystal structure of a glutamate-1-semialdehyde-aminomutase from Pseudomonas aeruginosa PAO1 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.44 X-RAY DIFFRACTION 100.0
5YKT TRANSFERASE 10/16/17 Crystal structure of a glutamate-1-semialdehyde-aminomutase (K286A) from Pseudomonas aeruginosa PAO1 in complex with PMP Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 1.57 X-RAY DIFFRACTION 99.8

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 627 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001602 (650 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4088

Human Homologs

References

Crystal structure of a glutamate-1-semialdehyde-aminomutase from Pseudomonas aeruginosa PAO1.
Li S, Lou X, Xu Y, Teng X, Che S, Liu R, Bartlam M
Biochem Biophys Res Commun 2018 Jun 7;500(3):804-809
PubMed ID: 29684343