Pseudomonas aeruginosa PAO1, PA4091 (hpaA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4091
Name
hpaA
Replicon chromosome
Genomic location 4573741 - 4575303 (+ strand)
Transposon Mutants 5 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252780.1
GI 15599286
Affymetrix PA4091_hpaA_at
Entrez 878727
GenBank AAG07478.1
INSDC AAG07478.1
NCBI Locus Tag PA4091
protein_id(GenBank) gb|AAG07478.1|AE004825_7|gnl|PseudoCAP|PA4091
TIGR NTL03PA04091
UniParc UPI00000C5C05
UniProtKB Acc Q9HWT7
UniProtKB ID Q9HWT7_PSEAE
UniRef100 UniRef100_W0YXR0
UniRef50 UniRef50_Q57160
UniRef90 UniRef90_A6V008

Product

Feature Type CDS
Coding Frame 1
Product Name
4-hydroxyphenylacetate 3-monooxygenase large chain
Product Name Confidence: Class 2
Synonyms p-hydroxyphenylacetate 3-hydroxylase
Evidence for Translation
Charge (pH 7) -6.58
Kyte-Doolittle Hydrophobicity Value -0.338
Molecular Weight (kDa) 58.5
Isoelectric Point (pI) 6.00

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 124 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001600 (316 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4091
Search term: hpaA

Human Homologs

References

Molecular characterization of 4-hydroxyphenylacetate 3-hydroxylase of Escherichia coli. A two-protein component enzyme.
Prieto MA, Garcia JL
J Biol Chem 1994 Sep 9;269(36):22823-9
PubMed ID: 8077235
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
Prieto MA, Díaz E, García JL
J Bacteriol 1996 Jan;178(1):111-20
PubMed ID: 8550403
Identification of a novel positive regulator of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli.
Prieto MA, García JL
Biochem Biophys Res Commun 1997 Mar 27;232(3):759-65
PubMed ID: 9126350