Pseudomonas aeruginosa PAO1, PA4114

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4114
Name
Synonym: bltD
Replicon chromosome
Genomic location 4601574 - 4602083 (- strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252803.1
GI 15599309
Affymetrix PA4114_at
Entrez 880872
GenBank AAG07501.1
INSDC AAG07501.1
NCBI Locus Tag PA4114
protein_id(GenBank) gb|AAG07501.1|AE004828_2|gnl|PseudoCAP|PA4114
TIGR NTL03PA04114
UniParc UPI00000C5C19
UniProtKB Acc Q9HWR6
UniProtKB ID Q9HWR6_PSEAE
UniRef100 UniRef100_W0YZK0
UniRef50 UniRef50_A6UZX9
UniRef90 UniRef90_A6UZX9

Product

Feature Type CDS
Coding Frame 1
Product Name
lysine decarboxylase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) 9.85
Kyte-Doolittle Hydrophobicity Value -0.331
Molecular Weight (kDa) 18.9
Isoelectric Point (pI) 10.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 61 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001584 (299 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4114

Human Homologs

References

Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated.
Ahmed M, Lyass L, Markham PN, Taylor SS, Vázquez-Laslop N, Neyfakh AA
J Bacteriol 1995 Jul;177(14):3904-10
PubMed ID: 7608059
Efflux of the natural polyamine spermidine facilitated by the Bacillus subtilis multidrug transporter Blt.
Woolridge DP, Vazquez-Laslop N, Markham PN, Chevalier MS, Gerner EW, Neyfakh AA
J Biol Chem 1997 Apr 4;272(14):8864-6
PubMed ID: 9083003
Cadaverine suppresses persistence to carboxypenicillins in Pseudomonas aeruginosa PAO1.
Manuel J, Zhanel GG, de Kievit T
Antimicrob Agents Chemother 2010 Dec;54(12):5173-9
PubMed ID: 20855735