Pseudomonas aeruginosa PAO1, PA4124 (hpcB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4124
Name
hpcB
Synonym: hpaD
Replicon chromosome
Genomic location 4612605 - 4613528 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252813.1
GI 15599319
Affymetrix PA4124_hpcB_at
DNASU PaCD00007797
Entrez 880101
GenBank AAG07511.1
INSDC AAG07511.1
NCBI Locus Tag PA4124
protein_id(GenBank) gb|AAG07511.1|AE004829_1|gnl|PseudoCAP|PA4124
TIGR NTL03PA04124
UniParc UPI00000C5C21
UniProtKB Acc Q9HWQ7
UniProtKB ID Q9HWQ7_PSEAE
UniRef100 UniRef100_W0YZK9
UniRef50 UniRef50_A4YWW9
UniRef90 UniRef90_A6UZW9

Product

Feature Type CDS
Coding Frame 1
Product Name
homoprotocatechuate 2,3-dioxygenase
Product Name Confidence: Class 2
Synonyms 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPC dioxygenase)
Evidence for Translation
Charge (pH 7) -7.61
Kyte-Doolittle Hydrophobicity Value -0.134
Molecular Weight (kDa) 33.4
Isoelectric Point (pI) 6.10

Subcellular localization

Individual Mappings
Localization Confidence PMID
Unknown Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 53 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001575 (385 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4124
Search term: hpcB

Human Homologs

References

Subcloning and nucleotide sequence of the 3,4-dihydroxyphenylacetate (homoprotocatechuate) 2,3-dioxygenase gene from Escherichia coli C.
Roper DI, Cooper RA
FEBS Lett 1990 Nov 26;275(1-2):53-7
PubMed ID: 2261999
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
Prieto MA, Díaz E, García JL
J Bacteriol 1996 Jan;178(1):111-20
PubMed ID: 8550403