Pseudomonas aeruginosa PAO1, PA4127 (hpcG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4127
Name
hpcG
Synonym: hpaH
Replicon chromosome
Genomic location 4615346 - 4616149 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252816.1
GI 15599322
Affymetrix PA4127_hpcG_at
DNASU PaCD00007799
Entrez 880260
GenBank AAG07514.1
INSDC AAG07514.1
NCBI Locus Tag PA4127
protein_id(GenBank) gb|AAG07514.1|AE004829_4|gnl|PseudoCAP|PA4127
TIGR NTL03PA04127
UniParc UPI00000C5C24
UniProtKB Acc Q9HWQ4
UniProtKB ID Q9HWQ4_PSEAE
UniRef100 UniRef100_W0YXV7
UniRef50 UniRef50_A5VW11
UniRef90 UniRef90_A6UZW6

Product

Feature Type CDS
Coding Frame 1
Product Name
2-oxo-hept-3-ene-1,7-dioate hydratase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Charge (pH 7) -5.37
Kyte-Doolittle Hydrophobicity Value 0.012
Molecular Weight (kDa) 29.2
Isoelectric Point (pI) 5.01

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 160 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001572 (401 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4127
Search term: hpcG

Human Homologs

References

Sequence of the hpcC and hpcG genes of the meta-fission homoprotocatechuic acid pathway of Escherichia coli C: nearly 40% amino-acid identity with the analogous enzymes of the catechol pathway.
Roper DI, Stringfellow JM, Cooper RA
Gene 1995 Apr 14;156(1):47-51
PubMed ID: 7737515
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
Prieto MA, Díaz E, García JL
J Bacteriol 1996 Jan;178(1):111-20
PubMed ID: 8550403