Pseudomonas aeruginosa PAO1, PA4138 (tyrS)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4138
Name
tyrS
Replicon chromosome
Genomic location 4627947 - 4629185 (- strand)
Transposon Mutants 5 transposon mutants in PAO1

Cross-References

RefSeq NP_252827.1
GI 15599333
Affymetrix PA4138_tyrS_at
Entrez 880105
GenBank AAG07525.1
INSDC AAG07525.1
NCBI Locus Tag PA4138
protein_id(GenBank) gb|AAG07525.1|AE004830_6|gnl|PseudoCAP|PA4138
TIGR NTL03PA04138
UniParc UPI00000C5C2F
UniProtKB Acc Q9HWP3
UniProtKB ID SYY1_PSEAE
UniRef100 UniRef100_Q9HWP3
UniRef50 UniRef50_Q9HWP3
UniRef90 UniRef90_Q9HWP3

Product

Feature Type CDS
Coding Frame 1
Product Name
tyrosyl-tRNA synthetase
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.71
Kyte-Doolittle Hydrophobicity Value -0.156
Molecular Weight (kDa) 45.1
Isoelectric Point (pI) 6.76

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 592 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001561 (307 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4138
Search term: tyrS

Human Homologs

Ensembl 110, assembly GRCh38.p14
tyrosyl-tRNA synthetase 2 [Source:HGNC Symbol;Acc:HGNC:24249]
E-value: 6.8e-55
Percent Identity: 33.5

References

Overproduction of tyrosyl-tRNA synthetase is toxic to Escherichia coli: a genetic analysis.
Bedouelle H, Guez V, Vidal-Cros A, Hermann M
J Bacteriol 1990 Jul;172(7):3940-5
PubMed ID: 2113914