Pseudomonas aeruginosa PAO1, PA4180

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4180
Name
Replicon chromosome
Genomic location 4676282 - 4677925 (- strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252869.1
GI 15599375
Affymetrix PA4180_at
Entrez 880313
GenBank AAG07567.1
INSDC AAG07567.1
NCBI Locus Tag PA4180
protein_id(GenBank) gb|AAG07567.1|AE004834_7|gnl|PseudoCAP|PA4180
TIGR NTL03PA04180
UniParc UPI00000C5C59
UniProtKB Acc Q9HWK1
UniProtKB ID Q9HWK1_PSEAE
UniRef100 UniRef100_A0A0A8RA44
UniRef50 UniRef50_A8EWP0
UniRef90 UniRef90_W0YYL9

Product

Feature Type CDS
Coding Frame 1
Product Name
probable acetolactate synthase large subunit
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.76
Kyte-Doolittle Hydrophobicity Value -0.047
Molecular Weight (kDa) 59.8
Isoelectric Point (pI) 6.28

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 594 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001520 (361 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4180

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
Cloning, sequencing and heterologous expression of a Klebsiella pneumoniae gene encoding an FAD-independent acetolactate synthase.
Peng HL, Wang PY, Wu CM, Hwang DC, Chang HY
Gene 1992 Aug 1;117(1):125-30
PubMed ID: 1644303
Characterization of the genes of the 2,3-butanediol operons from Klebsiella terrigena and Enterobacter aerogenes.
Blomqvist K, Nikkola M, Lehtovaara P, Suihko ML, Airaksinen U, Stråby KB, Knowles JK, Penttilä ME
J Bacteriol 1993 Mar;175(5):1392-404
PubMed ID: 8444801