Pseudomonas aeruginosa PAO1, PA4187

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4187
Name
Synonym: yaaU
Replicon chromosome
Genomic location 4683697 - 4685025 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252876.1
GI 15599382
Affymetrix PA4187_at
Entrez 880334
GenBank AAG07574.1
INSDC AAG07574.1
NCBI Locus Tag PA4187
protein_id(GenBank) gb|AAG07574.1|AE004835_3|gnl|PseudoCAP|PA4187
TIGR NTL03PA04187
UniParc UPI00000C5C60
UniProtKB Acc Q9HWJ4
UniProtKB ID Q9HWJ4_PSEAE
UniRef100 UniRef100_W0YWS7
UniRef50 UniRef50_A0A077JIH4
UniRef90 UniRef90_W0YWS7

Product

Feature Type CDS
Coding Frame 1
Product Name
probable major facilitator superfamily (MFS) transporter
Product Name Confidence: Class 3
Synonyms probable MFS transporter
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 8.86
Kyte-Doolittle Hydrophobicity Value 0.748
Molecular Weight (kDa) 47.6
Isoelectric Point (pI) 9.67

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 356 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001513 (768 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4187

Human Homologs

Ensembl 110, assembly GRCh38.p14
solute carrier family 22 member 2 [Source:HGNC Symbol;Acc:HGNC:10966]
E-value: 5.7e-07
Percent Identity: 26.0

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295