Pseudomonas aeruginosa PAO1, PA4189

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4189
Name
Replicon chromosome
Genomic location 4685994 - 4687484 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252878.1
GI 15599384
Affymetrix PA4189_at
Entrez 880328
GenBank AAG07576.1
INSDC AAG07576.1
NCBI Locus Tag PA4189
protein_id(GenBank) gb|AAG07576.1|AE004835_5|gnl|PseudoCAP|PA4189
TIGR NTL03PA04189
UniParc UPI00000C5C62
UniProtKB Acc Q9HWJ2
UniProtKB ID Q9HWJ2_PSEAE
UniRef100 UniRef100_W0YYM9
UniRef50 UniRef50_A0A085H6C2
UniRef90 UniRef90_V6A9V5

Product

Feature Type CDS
Coding Frame 1
Product Name
probable aldehyde dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Charge (pH 7) -13.53
Kyte-Doolittle Hydrophobicity Value -0.006
Molecular Weight (kDa) 53.4
Isoelectric Point (pI) 5.07

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
7UYY OXIDOREDUCTASE 05/07/22 The crystal structure of the Pseudomonas aeruginosa aldehyde dehydrogenase encoded by the PA4189 gene in complex with NADH Pseudomonas aeruginosa PAO1 2.7 X-RAY DIFFRACTION 100.0

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 601 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001512 (334 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4189

Human Homologs

Ensembl 110, assembly GRCh38.p14
aldehyde dehydrogenase 1 family member L2 [Source:HGNC Symbol;Acc:HGNC:26777]
E-value: 1.6e-98
Percent Identity: 39.9
Ensembl 110, assembly GRCh38.p14
aldehyde dehydrogenase 1 family member A1 [Source:HGNC Symbol;Acc:HGNC:402]
E-value: 1.6e-98
Percent Identity: 41.2
Ensembl 110, assembly GRCh38.p14
aldehyde dehydrogenase 1 family member L2 [Source:HGNC Symbol;Acc:HGNC:26777]
E-value: 1.6e-98
Percent Identity: 39.9

References

p-Cumate catabolic pathway in Pseudomonas putida Fl: cloning and characterization of DNA carrying the cmt operon.
Eaton RW
J Bacteriol 1996 Mar;178(5):1351-62
PubMed ID: 8631713