Pseudomonas aeruginosa PAO1, PA4198

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4198
Name
Replicon chromosome
Genomic location 4696281 - 4697903 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252887.1
GI 15599393
Affymetrix PA4198_at
Entrez 880351
GenBank AAG07585.1
INSDC AAG07585.1
NCBI Locus Tag PA4198
protein_id(GenBank) gb|AAG07585.1|AE004836_4|gnl|PseudoCAP|PA4198
TIGR NTL03PA04198
UniParc UPI00000C5C6B
UniProtKB Acc Q9HWI3
UniProtKB ID Q9HWI3_PSEAE
UniRef100 UniRef100_A0A072ZPR9
UniRef50 UniRef50_Q9SS01
UniRef90 UniRef90_A0A072ZPR9

Product

Feature Type CDS
Coding Frame 1
Product Name
probable AMP-binding enzyme
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Detected by iTRAQ (PMID:21863142).
Charge (pH 7) -11.49
Kyte-Doolittle Hydrophobicity Value -0.038
Molecular Weight (kDa) 59.5
Isoelectric Point (pI) 6.15

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 2
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 601 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001508 (405 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4198

Human Homologs

Ensembl 110, assembly GRCh38.p14
acyl-CoA synthetase family member 2 [Source:HGNC Symbol;Acc:HGNC:26101]
E-value: 2.4e-44
Percent Identity: 29.0
Ensembl 110, assembly GRCh38.p14
acyl-CoA synthetase family member 2 [Source:HGNC Symbol;Acc:HGNC:26101]
E-value: 2.4e-44
Percent Identity: 29.0

References

Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142