Pseudomonas aeruginosa PAO1, PA4199

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4199
Name
Replicon chromosome
Genomic location 4698021 - 4699802 (+ strand)
Transposon Mutants 3 transposon mutants in PAO1
Transposon Mutants in orthologs 12 transposon mutants in orthologs

Cross-References

RefSeq NP_252888.1
GI 15599394
Affymetrix PA4199_at
Entrez 880396
GenBank AAG07586.1
INSDC AAG07586.1
NCBI Locus Tag PA4199
protein_id(GenBank) gb|AAG07586.1|AE004836_5|gnl|PseudoCAP|PA4199
TIGR NTL03PA04199
UniParc UPI00000C5C6C
UniProtKB Acc Q9HWI2
UniProtKB ID Q9HWI2_PSEAE
UniRef100 UniRef100_N2D1H2
UniRef50 UniRef50_B3PNQ8
UniRef90 UniRef90_A6UZQ0

Product

Feature Type CDS
Coding Frame 1
Product Name
probable acyl-CoA dehydrogenase
Product Name Confidence: Class 3
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by iTRAQ (PMID:21863142).
Charge (pH 7) -14.51
Kyte-Doolittle Hydrophobicity Value -0.034
Molecular Weight (kDa) 63.9
Isoelectric Point (pI) 5.02

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 433 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG000493 (2496 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4199

Human Homologs

Ensembl 110, assembly GRCh38.p14
acyl-CoA dehydrogenase very long chain [Source:HGNC Symbol;Acc:HGNC:92]
E-value: 1.3e-19
Percent Identity: 27.2
Ensembl 110, assembly GRCh38.p14
acyl-CoA dehydrogenase very long chain [Source:HGNC Symbol;Acc:HGNC:92]
E-value: 1.3e-19
Percent Identity: 27.2
Ensembl 110, assembly GRCh38.p14
acyl-CoA dehydrogenase very long chain [Source:HGNC Symbol;Acc:HGNC:92]
E-value: 1.3e-19
Percent Identity: 27.2

References

Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142