Pseudomonas aeruginosa PAO1, PA4205 (mexG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4205
Name
mexG
Replicon chromosome
Genomic location 4705956 - 4706402 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252894.1
GI 15599400
Affymetrix PA4205_at
Entrez 880449
GenBank AAG07592.1
INSDC AAG07592.1
NCBI Locus Tag PA4205
protein_id(GenBank) gb|AAG07592.1|AE004837_3|gnl|PseudoCAP|PA4205
TIGR NTL03PA04205
UniParc UPI00000C5C72
UniProtKB Acc Q9HWH6
UniProtKB ID Q9HWH6_PSEAE
UniRef100 UniRef100_W0YYS7
UniRef50 UniRef50_B2FNW8
UniRef90 UniRef90_A6UZP4

Product

Feature Type CDS
Coding Frame 1
Product Name
hypothetical protein
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) 2.43
Kyte-Doolittle Hydrophobicity Value 0.734
Molecular Weight (kDa) 16.2
Isoelectric Point (pI) 9.22

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexG MexG is a membrane protein required for MexGHI-OpmD efflux activity. [PMID:12917802, PMID:15817779] ARO:3000806 protein homolog model Perfect 276.6 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 58 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001502 (300 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4205
Search term: mexG

Human Homologs

References

Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium.
Aendekerk S, Ghysels B, Cornelis P, Baysse C
Microbiology (Reading) 2002 Aug;148(Pt 8):2371-2381
PubMed ID: 12177331
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295