Pseudomonas aeruginosa PAO1, PA4206 (mexH)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4206
Name
mexH
Replicon chromosome
Genomic location 4706410 - 4707522 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252895.1
GI 15599401
Affymetrix PA4206_at
DNASU PaCD00007827
Entrez 880450
GenBank AAG07593.1
INSDC AAG07593.1
NCBI Locus Tag PA4206
protein_id(GenBank) gb|AAG07593.1|AE004837_4|gnl|PseudoCAP|PA4206
TIGR NTL03PA04206
UniParc UPI00000C5C73
UniProtKB Acc Q9HWH5
UniProtKB ID Q9HWH5_PSEAE
UniRef100 UniRef100_W0YVS7
UniRef50 UniRef50_W0YVS7
UniRef90 UniRef90_W0YVS7

Product

Feature Type CDS
Coding Frame 1
Product Name
probable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor
Product Name Confidence: Class 1
Synonyms probable RND efflux membrane fusion protein precursor
Evidence for Translation
Charge (pH 7) 2.70
Kyte-Doolittle Hydrophobicity Value 0.005
Molecular Weight (kDa) 39.2
Isoelectric Point (pI) 8.95

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AMR gene predictions from CARD database

Identified using the Resistance Gene Identifier (RGI)

Model Name Definition Accession Model Type (?) SNP Cutoff Bit Score Percent Identity CARD Version
MexH MexH is the membrane fusion protein of the efflux complex MexGHI-OpmD. [PMID:12917802, PMID:15817779] ARO:3000807 protein homolog model Perfect 688.3 100.0 3.2.5

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 450 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001501 (811 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4206
Search term: mexH

Human Homologs

References

Characterization of a new efflux pump, MexGHI-OpmD, from Pseudomonas aeruginosa that confers resistance to vanadium.
Aendekerk S, Ghysels B, Cornelis P, Baysse C
Microbiology (Reading) 2002 Aug;148(Pt 8):2371-2381
PubMed ID: 12177331
Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295