Pseudomonas aeruginosa PAO1, PA4214 (phzE1)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4214
Name
phzE1
Replicon chromosome
Genomic location 4716660 - 4718543 (+ strand)
Transposon Mutants 2 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252903.1
GI 15599409
Entrez 880505
GenBank AAG07601.1
NCBI Locus Tag PA4214
protein_id(GenBank) gb|AAG07601.1|AE004838_5|gnl|PseudoCAP|PA4214
TIGR NTL03PA04214
UniProtKB Acc Q7DC81
UniProtKB ID Q7DC81_PSEAE

Product

Feature Type CDS
Coding Frame 1
Product Name
phenazine biosynthesis protein PhzE
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -13.46
Kyte-Doolittle Hydrophobicity Value -0.180
Molecular Weight (kDa) 69.0
Isoelectric Point (pI) 5.45

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB
Category Phenazine biosynthesis
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 591 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001493 (402 members)
Putative Inparalogs 1 predicted inparalogs
phenazine biosynthesis protein PhzE (PA1903) 100.0% identity

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4214
Search term: phzE1

Human Homologs

References

Functional analysis of genes for biosynthesis of pyocyanin and phenazine-1-carboxamide from Pseudomonas aeruginosa PAO1.
Mavrodi DV, Bonsall RF, Delaney SM, Soule MJ, Phillips G, Thomashow LS
J Bacteriol 2001 Nov;183(21):6454-65
PubMed ID: 11591691
Molecular analysis of genes encoding phenazine biosynthesis in the biological control bacterium. Pseudomonas aureofaciens 30-84.
Pierson LS 3rd, Gaffney T, Lam S, Gong F
FEMS Microbiol Lett 1995 Dec 15;134(2-3):299-307
PubMed ID: 8586283