Pseudomonas aeruginosa PAO1, PA4224 (pchG)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4224
Name
pchG
Replicon chromosome
Genomic location 4730323 - 4731372 (- strand)
Transposon Mutants 2 transposon mutants in PAO1

Cross-References

RefSeq NP_252914.1
GI 15599420
Affymetrix PA4224_at
DNASU PaCD00007833
Entrez 880082
GenBank AAG07612.1
INSDC AAG07612.1
NCBI Locus Tag PA4224
protein_id(GenBank) gb|AAG07612.1|AE004839_5|gnl|PseudoCAP|PA4224
TIGR NTL03PA04225
UniParc UPI00000C6EAE
UniProtKB Acc Q9HWG5
UniProtKB ID Q9HWG5_PSEAE
UniRef100 UniRef100_Q9HWG5
UniRef50 UniRef50_Q9HWG5
UniRef90 UniRef90_Q9HWG5

Product

Feature Type CDS
Coding Frame 1
Product Name
pyochelin biosynthetic protein PchG
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Charge (pH 7) -8.93
Kyte-Doolittle Hydrophobicity Value 0.097
Molecular Weight (kDa) 37.7
Isoelectric Point (pI) 4.90

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Virulence Evidence

Source 1
Database VFDB : VF0095
Category Pyochelin
Evidence
Host Organism
Notes
Reference

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 39 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001484 (303 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4224
Search term: pchG

Human Homologs

References

Essential PchG-dependent reduction in pyochelin biosynthesis of Pseudomonas aeruginosa.
Reimmann C, Patel HM, Serino L, Barone M, Walsh CT, Haas D
J Bacteriol 2001 Feb;183(3):813-20
PubMed ID: 11208777