Pseudomonas aeruginosa PAO1, PA4234 (uvrA)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4234
Name
uvrA
Replicon chromosome
Genomic location 4748756 - 4751593 (+ strand)
Transposon Mutants 6 transposon mutants in PAO1
Transposon Mutants in orthologs 2 transposon mutants in orthologs

Cross-References

RefSeq NP_252924.1
GI 15599430
Affymetrix PA4234_uvrA_at
Entrez 881827
GenBank AAG07622.1
INSDC AAG07622.1
NCBI Locus Tag PA4234
protein_id(GenBank) gb|AAG07622.1|AE004840_8|gnl|PseudoCAP|PA4234
TIGR NTL03PA04235
UniParc UPI0000137E8F
UniProtKB Acc Q9HWG0
UniProtKB ID UVRA_PSEAE
UniRef100 UniRef100_Q9HWG0
UniRef50 UniRef50_Q890X9
UniRef90 UniRef90_Q9HWG0

Product

Feature Type CDS
Coding Frame 1
Product Name
excinuclease ABC subunit A
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -5.31
Kyte-Doolittle Hydrophobicity Value -0.288
Molecular Weight (kDa) 104.5
Isoelectric Point (pI) 6.61

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 659 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001476 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4234
Search term: uvrA

Human Homologs

References

Sequences of Escherichia coli uvrA gene and protein reveal two potential ATP binding sites.
Husain I, Van Houten B, Thomas DC, Sancar A
J Biol Chem 1986 Apr 15;261(11):4895-901
PubMed ID: 3007478
Evidence from extended X-ray absorption fine structure and site-specific mutagenesis for zinc fingers in UvrA protein of Escherichia coli.
Navaratnam S, Myles GM, Strange RW, Sancar A
J Biol Chem 1989 Sep 25;264(27):16067-71
PubMed ID: 2550431