Pseudomonas aeruginosa PAO1, PA4243 (secY)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4243
Name
secY
Synonym: prlA
Replicon chromosome
Genomic location 4757124 - 4758452 (- strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_252933.1
GI 15599439
Affymetrix PA4243_secY_at
Entrez 881804
GenBank AAG07631.1
INSDC AAG07631.1
NCBI Locus Tag PA4243
protein_id(GenBank) gb|AAG07631.1|AE004841_9|gnl|PseudoCAP|PA4243
TIGR NTL03PA04244
UniParc UPI00000C5C80
UniProtKB Acc Q9HWF5
UniProtKB ID SECY_PSEAE
UniRef100 UniRef100_Q9HWF5
UniRef50 UniRef50_P78283
UniRef90 UniRef90_Q9HWF5

Product

Feature Type CDS
Coding Frame 1
Product Name
secretion protein SecY
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) 14.37
Kyte-Doolittle Hydrophobicity Value 0.576
Molecular Weight (kDa) 47.8
Isoelectric Point (pI) 10.25

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Membrane Class 2
Cytoplasmic Membrane Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 612 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG001467 (536 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4243
Search term: secY

Human Homologs

References

Genome-wide identification of Pseudomonas aeruginosa exported proteins using a consensus computational strategy combined with a laboratory-based PhoA fusion screen.
Lewenza S, Gardy JL, Brinkman FS, Hancock RE
Genome Res 2005 Feb;15(2):321-9
PubMed ID: 15687295
The spc ribosomal protein operon of Escherichia coli: sequence and cotranscription of the ribosomal protein genes and a protein export gene.
Cerretti DP, Dean D, Davis GR, Bedwell DM, Nomura M
Nucleic Acids Res 1983 May 11;11(9):2599-616
PubMed ID: 6222285
Characterization of cold-sensitive secY mutants of Escherichia coli.
Baba T, Jacq A, Brickman E, Beckwith J, Taura T, Ueguchi C, Akiyama Y, Ito K
J Bacteriol 1990 Dec;172(12):7005-10
PubMed ID: 2254269
The allele-specific synthetic lethality of prlA-prlG double mutants predicts interactive domains of SecY and SecE.
Flower AM, Osborne RS, Silhavy TJ
EMBO J 1995 Mar 1;14(5):884-93
PubMed ID: 7889938