Pseudomonas aeruginosa PAO1, PA4283 (recD)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4283
Name
recD
Replicon chromosome
Genomic location 4799299 - 4801464 (- strand)
Transposon Mutants 1 transposon mutants in PAO1

Cross-References

RefSeq NP_252973.1
GI 15599479
Affymetrix PA4283_recD_at
Entrez 881652
GenBank AAG07671.1
INSDC AAG07671.1
NCBI Locus Tag PA4283
protein_id(GenBank) gb|AAG07671.1|AE004844_3|gnl|PseudoCAP|PA4283
TIGR NTL03PA04284
UniParc UPI00000C5C94
UniProtKB Acc Q9HWB7
UniProtKB ID Q9HWB7_PSEAE
UniRef100 UniRef100_Q9HWB7
UniRef50 UniRef50_Q4KIQ4
UniRef90 UniRef90_Q9HWB7

Product

Feature Type CDS
Coding Frame 1
Product Name
exodeoxyribonuclease V alpha chain
Product Name Confidence: Class 2
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -3.53
Kyte-Doolittle Hydrophobicity Value -0.163
Molecular Weight (kDa) 79.1
Isoelectric Point (pI) 6.65

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 304 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003886 (533 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4283
Search term: recD

Human Homologs

References

recD: the gene for an essential third subunit of exonuclease V.
Amundsen SK, Taylor AF, Chaudhury AM, Smith GR
Proc Natl Acad Sci U S A 1986 Aug;83(15):5558-62
PubMed ID: 3526335
Complete nucleotide sequence of the Escherichia coli recB gene.
Finch PW, Storey A, Chapman KE, Brown K, Hickson ID, Emmerson PT
Nucleic Acids Res 1986 Nov 11;14(21):8573-82
PubMed ID: 3537960
Cloning of the recB, recC, and recD genes from Proteus mirabilis in Escherichia coli: in vivo formation of active hybrid enzymes.
Weichenhan D, Wackernagel W
J Bacteriol 1988 Mar;170(3):1412-4
PubMed ID: 3277957
The genetic dependence of recombination in recD mutants of Escherichia coli.
Lovett ST, Luisi-DeLuca C, Kolodner RD
Genetics 1988 Sep;120(1):37-45
PubMed ID: 3065139
Biochemical and physical characterization of exonuclease V from Escherichia coli. Comparison of the catalytic activities of the RecBC and RecBCD enzymes.
Palas KM, Kushner SR
J Biol Chem 1990 Feb 25;265(6):3447-54
PubMed ID: 2154479
Chi and the RecBC D enzyme of Escherichia coli.
Myers RS, Stahl FW
Annu Rev Genet 1994;28:49-70
PubMed ID: 7893137