Pseudomonas aeruginosa PAO1, PA4296 (pprB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4296
Name
pprB
Synonym: pprB
Replicon chromosome
Genomic location 4820532 - 4821359 (+ strand)
Transposon Mutants 4 transposon mutants in PAO1
Transposon Mutants in orthologs 1 transposon mutants in orthologs

Cross-References

RefSeq NP_252986.1
GI 15599492
Affymetrix PA4296_at
Entrez 881658
GenBank AAG07684.1
INSDC AAG07684.1
NCBI Locus Tag PA4296
protein_id(GenBank) gb|AAG07684.1|AE004846_1|gnl|PseudoCAP|PA4296
TIGR NTL03PA04297
UniParc UPI00000C5CA1
UniProtKB Acc Q9HWA4
UniProtKB ID Q9HWA4_PSEAE
UniRef100 UniRef100_Q9HWA4
UniRef50 UniRef50_Q9HWA4
UniRef90 UniRef90_Q9HWA4

Product

Feature Type CDS
Coding Frame 1
Product Name
two-component response regulator, PprB
Product Name Confidence: Class 1
Synonyms two-component response regulator, PprB
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Charge (pH 7) -1.42
Kyte-Doolittle Hydrophobicity Value -0.329
Molecular Weight (kDa) 30.6
Isoelectric Point (pI) 6.74

Subcellular localization

Individual Mappings
Localization Confidence PMID
Cytoplasmic Class 3
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 567 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003897 (470 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4296
Search term: pprB

Human Homologs

References

Regulation of membrane permeability by a two-component regulatory system in Pseudomonas aeruginosa.
Wang Y, Ha U, Zeng L, Jin S
Antimicrob Agents Chemother 2003 Jan;47(1):95-101
PubMed ID: 12499175
Pseudomonas aeruginosa AlgB, which modulates the expression of alginate, is a member of the NtrC subclass of prokaryotic regulators.
Goldberg JB, Dahnke T
Mol Microbiol 1992 Jan;6(1):59-66
PubMed ID: 1738315