Pseudomonas aeruginosa PAO1, PA4366 (sodB)

Cytoplasmic
Cytoplasmic Membrane
Periplasmic
Outer Membrane
Extracellular
Unknown
View in JBrowse PseudoCyc / Metabolic Pathways

Gene Feature Overview

Strain Pseudomonas aeruginosa PAO1 (Stover et al., 2000)
GCF_000006765.1|latest
Locus Tag
PA4366
Name
sodB
Replicon chromosome
Genomic location 4893697 - 4894278 (+ strand)

Cross-References

RefSeq NP_253056.1
GI 15599562
Affymetrix PA4366_sodB_at
Entrez 881397
GenBank AAG07754.1
INSDC AAG07754.1
NCBI Locus Tag PA4366
protein_id(GenBank) gb|AAG07754.1|AE004852_7|gnl|PseudoCAP|PA4366
TIGR NTL03PA04367
UniParc UPI0000165ED5
UniProtKB Acc P53641
UniProtKB ID SODF_PSEAE
UniRef100 UniRef100_P53641
UniRef50 UniRef50_P09223
UniRef90 UniRef90_P09223

Product

Feature Type CDS
Coding Frame 1
Product Name
superoxide dismutase
Product Name Confidence: Class 1
Synonyms
Evidence for Translation
Identified using nanoflow high-pressure liquid chromatography (HPLC) in conjunction with microelectrospray ionization on LTQ XL mass spectrometer (PMID:24291602).
Detected by MALDI-TOF/TOF (PMID:19333994).
Detected by two-dimensional gel electrophoresis and mass spectral analysis(PMID:21863142).
Charge (pH 7) -6.39
Kyte-Doolittle Hydrophobicity Value -0.288
Molecular Weight (kDa) 21.4
Isoelectric Point (pI) 5.21

Subcellular localization

Individual Mappings
Localization Confidence PMID
Periplasmic Class 3
Periplasmic Class 1
Additional evidence for subcellular localization

AlphaFold 2 Protein Structure Predictions

Protein structure predictions using a neural network model developed by DeepMind. If a UniProtKB accession is associated with this protein, a search link will be provided below.

Look for predicted 3D structure in AlphaFold DB: Search

PDB 3D Structures

Accession Header Accession Date Compound Source Resolution Method Percent Identity
3SDP OXIDOREDUCTASE (SUPEROXIDE ACCEPTOR) 05/06/91 THE 2.1 ANGSTROMS RESOLUTION STRUCTURE OF IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS Pseudomonas putida 2.1 X-RAY DIFFRACTION 91.5
1DT0 OXIDOREDUCTASE 01/10/00 CLONING, SEQUENCE, AND CRYSTALLOGRAPHIC STRUCTURE OF RECOMBINANT IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS Pseudomonas putida 2.1 X-RAY DIFFRACTION 92.1

Pathogen Association Analysis

Results
Common
Found in both pathogen and nonpathogenic strains
Hits to this gene were found in 530 genera

Orthologs/Comparative Genomics

Pseudomonas Ortholog Database View orthologs at Pseudomonas Ortholog Database
Pseudomonas Ortholog Group POG003959 (531 members)
Putative Inparalogs None Found

Interactions

STRING database Search for predicted protein-protein interactions using:
Search term: PA4366
Search term: sodB

Human Homologs

Ensembl 110, assembly GRCh38.p14
superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180]
E-value: 3.3e-44
Percent Identity: 47.0
Ensembl 110, assembly GRCh38.p14
superoxide dismutase 2 [Source:HGNC Symbol;Acc:HGNC:11180]
E-value: 3.3e-44
Percent Identity: 47.0

References

Proteome analysis reveals adaptation of Pseudomonas aeruginosa to the cystic fibrosis lung environment.
Sriramulu DD, Nimtz M, Romling U
Proteomics 2005 Sep;5(14):3712-21
PubMed ID: 16097035
Cloning and characterization of the Pseudomonas aeruginosa sodA and sodB genes encoding manganese- and iron-cofactored superoxide dismutase: demonstration of increased manganese superoxide dismutase activity in alginate-producing bacteria.
Hassett DJ, Woodruff WA, Wozniak DJ, Vasil ML, Cohen MS, Ohman DE
J Bacteriol 1993 Dec;175(23):7658-65
PubMed ID: 8244935
Analysis of the periplasmic proteome of Pseudomonas aeruginosa, a metabolically versatile opportunistic pathogen.
Imperi F, Ciccosanti F, Perdomo AB, Tiburzi F, Mancone C, Alonzi T, Ascenzi P, Piacentini M, Visca P, Fimia GM
Proteomics 2009 Apr;9(7):1901-15
PubMed ID: 19333994
Comparisons of Two Proteomic Analyses of Non-Mucoid and Mucoid Pseudomonas aeruginosa Clinical Isolates from a Cystic Fibrosis Patient.
Rao J, Damron FH, Basler M, Digiandomenico A, Sherman NE, Fox JW, Mekalanos JJ, Goldberg JB
Front Microbiol 2011;2:162
PubMed ID: 21863142